Dr Law Hui Nee Annie (刘慧妮医生)

Rheumatology

Credentials MB BCh BAO, MRCP (UK), MMed, FAMS (Rheumatology)
Language English, Mandarin Chinese, Behasa Melayu
Info

Education and Training
Dr Annie Law obtained her Bachelor of Medicine, Surgery and Obstetrics and Gynaecology (MB BCh BAO) from the National University of Ireland (Galway) in 2006. She was awarded Membership of Royal College of Physicians, United Kingdom and Master of Medicine, Singapore in 2011. After which, she pursued advanced specialist training in Rheumatology at Singapore General Hospital. She received her specialist Rheumatology and Immunology accreditation in 2015 from Singapore’s Ministry of Health and is registered under the Singapore Medical Council.

She was awarded the Singhealth Health Manpower Development Program Fellowships (HMDP) in “Management of Organ Specific Flares in Systemic Lupus Erythematosus with Appropriate Treat-to-Target Goals” in 2017. She did her fellowship at Monash University in Melbourne, Australia and was under the tutelage of Prof Eric Morand. Upon her return, she leverages on her experience and insights to treat complex lupus patients.

Publications
  • Refereed Journals 

 

  1. Diffuse Alveolar Haemorrhage in Systemic Lupus Erythematosus: A multicenter retrospective study in Singapore. Annie HN Law, Chua TY, Lee WX, Lian TY, Teh GG, Chew LC.  Lupus  2023 June; 32 (8): 1-12. Doi:org/10.1177/09612033231180704 
  1. From Silos to Prairies: Artificial Intelligence and High-Dimensional Technologies in the Theragnosis of Systemic Lupus Erythematous (SLE). Katherine Nay Yaung; Joo Guan Yeo; Pavanish Kumar; Martin Wasser; Marvin Chew; Angelo Ravelli; Annie Hui Nee Law; Thaschawee Arkachaisri; Alberto Martini; David S Pisetsky; Salvatore Albani. The Lancet Rheumatology 2023; 5: e151–65
  1. Ma M, Santosa A, Fong W, Chew LC, Low AH, Law A, Poh YJ, Yeo SI, Leung YY, Ng VW, Koh JZ, Tay SH, Mak A, Teng GG, Xu C, Tang JG, Kong KO, Angkodjojo S, Goh WR, Chuah TY, Roslan NE, Arkachaisri T, Teh KL, Sriranganathan M, Tan TC, Phang KF, Yap QV, Chan YH, Cheung PP, Lahiri M. Post-mRNA vaccine flares in autoimmune inflammatory rheumatic diseases: Results from the COronavirus National Vaccine registry for ImmuNe diseases SINGapore (CONVIN-SING). J Autoimmun. 2022 Nov 29;134:102959. doi: 10.1016/j.jaut.2022.102959. Epub ahead of print. PMID: 36473406; PMCID: PMC9705203.
  1. Connelly K, Kandane-Rathnayake R, Hoi A, Louthrenoo W, Hamijoyo L, Luo SF, Wu YJ, Cho J, Lateef A, Lau CS, Chen YH, Navarra S, Zamora L, Li Z, An Y, Sockalingam S, Hao Y, Zhang Z, Chan M, Katsumata Y, Harigai M, Oon S, Bae SC, O’Neill S, Gibson KA, Basnayake B, Kikuchi J, Takeuchi T, Ng KPL, Tugnet N, Kumar S, Goldblatt F, Law A, Tee M, Tee C, Tanaka Y, Ohkubo N, Tan JY, Karyekar CS, Nikpour M, Golder V, Morand EF. Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With Long-Term Clinical Outcomes: A Five-Year Prospective Study. Arthritis Rheumatol. 2022 Sep 19. doi: 10.1002/art.42350. Epub ahead of print. PMID: 36122172.
  1. Rangi Kandane-Rathnayake, Vera Golder, Worawit Louthrenoo, Yi-Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue-Fen Luo, Yeong-Jian J Wu, Sandra V Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Yanjie Hao, Zhuoli Zhang, B M D B Basnayake, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Sang-Cheol Bae, Shereen Oon, Sean O’Neill, Fiona Goldblatt, Kristine Pek Ling Ng, Annie Law, Nicola Tugnet, Sunil Kumar, Cherica Tee, Michael Tee, Naoaki Ohkubo, Yoshiya Tanaka, DaeYoung Yu, Chetan S Karyekar, Chak Sing Lau, Julie A Monk, Mandana Nikpour, Alberta Hoi, Eric F Morand. Lupus low disease activity state and remission and risk of mortality in patients with systemic lupus erythematosus: a prospective, multinational, longitudinal cohort study,The Lancet Rheumatology. Volume 4,Issue 12,2022,Pages e822-e830,ISSN 2665-9913,https://doi.org/10.1016/S2665-9913(22)00304-6.
  1. Supplementing CXCL5 dampens inflammation and improves survival in murine lupus via  myeloid and neutrophil pathways” by Fan, Xiubo; Ng, Chin Teck; Guo, Dianyang; Lim, Frances; Tan, Jia Chi; Law, Annie; Chen, Jinmiao; Poon, Zhi Yong; Cheung, Alice; Kong, Say Li; Loh, Hwai Liang; Tan, Michelle; Li, Shang; Lim, Kiat Hon; Thumboo, Julian; Hwang, William; Low, Andrea. Arthritis & Rheumatology. Oct 2022. 
  1. Neuropsychiatric lupus in Singapore: Disease characteristics and outcomes. Nur Emilia Roslan, Annie Hui Nee Law. J Rheum Dis Treat April 2022 8:094. doi.org/10.23937/2469-5726/1510094
  • COVID-19 infection in patients with systemic lupus erythematosus: Data from the Asia Pacific Lupus Collaboration. Jiacai Cho, Rangi Kandane-Rathnayake, Worawit Louthrenoo, Alberta Hoi, Vera Golder, Yi Hsing Chen, Shue Fen Luo, Yeong Jian Jan Wu, Laniyati Hamijoyo, Chak Sing Lau, Sandra Navarra, Leonid Zamora, Michael Tee, Angelito Flora, Zhan Guo Li, Yuan An, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Yanjie HaoShow lessZhuoli Zhang, Jun Kikuchi, Tsutomu Takeuchi, Duminda Basnayake, Fiona Goldblatt, Madelynn Chan, Kristine Pek Ling Ng, Sang Cheol Bae, Shereen Oon, Sean O’Neill, Kathy Gibson, Sunil Kumar, Annie Hui Nee Law, Nicola Tugnet, Yoshiya Tanaka, Mandy Nikpour, Eric Morand, Aisha Lateef. International Journal of Rheumatic Diseases, Sept 2020, 23(9), 1255-1257. https://doi.org/10.1111/1756-185X.13937
  1. A double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease. Low AHL1, Teng GG2, Pettersson S3, de Sessions PF4, Ho EXP4, Fan Q5, Chu CW4, Law AHN6, Santosa A2, Lim AYN2, Wang YT7, Haaland B5, Thumboo J8. Semin Arthritis Rheum 2019;49(3):411-419
  1. Neuropsychiatric Systemic Lupus Erythematosus in a geriatric patient: A case report. Sri Kumaran S, Law AHN. Case Report of Internal Medicine 2017,4:50-53
  1. Erdheim-Chester Disease: a case of cardiac and hypophyseal involvement showing positive response with high dose pegylated interferon-α. Law AHN, Yeo SI. Journal of Rheumatic Diseases and Treatment 2016,2:031
  1. Nail patella syndrome: A case report.

      Law HN, Chew LC. Proceedings of Singapore Healthcare 2013;22(1); 70-74

  • Non-refereed publications 
  • Review Articles – NA
  • Books & Chapters – NA
  1. Systemic lupus erythematosus: A diagnosis not to be missed.

Medical Grapevine. March 2015

 

  1. Scleroderma- National Arthritis Foundation Newsletter Oct 2016

 

  1. Management of SLE in primary care – MIMS March 2018

 

  • Abstracts
  1. Ten Topics Asia Rheumatology – Singapore October 2012

Validation of the UCLA Scleroderma Clinical trial Consortium Gastrointestinal tract instrument in English and Chinese speaking patients with Systemic Sclerosis. Law HN, Png ME, Teo HQ, Low HL.

  1. Ten Topics Asia Rheumatology – Singapore October 2012

Lower incidence of transaminitis and hyperferritineamia in Adult-onset Still’s disease in a Singaporean cohort. Fong WS, Law HN, Lui NL.

  1. European Respiratory Society – International Congress September 2016

Erdheim-Chester Disease- Patterns and pulmonary involvement. Teo F, Law A, Poon M, Ong CC, Chee C, Gin TC. 

  1. Singapore Society of Rheumatology- Malaysian Society of Rheumatology Conference – Singapore Aug 2017

A patient with MDA5 positive amyopathic dermatomyositis mistaken for Hand Foot & Mouth disease with pneumonia. Nur Emilia R, Law AHN.

  1. Indo UK Rheumatology Summit Jan 2018

A curious case of extensive tenosynovitis and subcutaneous nodules. Tan Tze Chin, Law AHN. Jan 2018

  1. EULAR June 2018

A proof-of concept double-blind randomized placebo-controlled trial of probiotics in Systemic Sclerosis associated gastrointestinal disease. A.H.L. Low, G.G. Teng, S. Pettersson, P.F De Sessions, Q.Fan, A.Law, A. Santosa, A.A.Lim, J.Thumboo

  1. Euro Echo Dec 2018

“Pseudo-prolapse” in mitral regurgitation post myocarditis. A.S.Y.Lee, M.R Amanullah, A.Law, H.C.Tang, S.H.Ewe, L.Y.Teo.

  1. EAFONS conference Jan 2019

Polymyxin B-Haemoperfusion in severe interstitial lung disease: safety and efficacy of low dose heparin. Tan HK, Fong W, Law A, Ng LC, Choong LHL, Foo MWY. 

  1. APLAR April 2019

Getting to the Bones of It: A clinical audit of osteoporosis management in an Australian SLE Cohort. R.Koelmeyer, V.Golder, A.Law, E.Morand and A.Hoi

  1. 23rd SGH Annual Scientific Meeting – Outstanding research award -basic/translational research

A mesenchymal stem cell-derived two factor combination mimics MSC to attenuate Systemic Lupus Erythematosus via suppressing Th1,Th17 and macrophages. Fan XBm Guan DY, Ng CT, AHN Law, Andrea Low HL, Thumboo J, Lim KH, William Hwang YK

  1. Anti-HMGCR myopathy presenting with chest pain and myocarditis. ESC Heart failure Congress Jan 2021 – Clinical case. Mingjin Gan, AHN Law, Loon Yee Teo.
  1. APLAR 2021. IgG4 related disease presenting as left mastoiditis in a patient previously diagnosed with right maxillary inflammatory myofibroblastic tumor. Maria Noviani,Tricia Chew Li Ting, Annie Law Hui Nee
  1. APLAR 2021 A multi-parametric interrogation of Systemic Lupus Erythematosus immunome reveals multiple derangements correlated to disease. Joo Guan Yeo, Katherine Nay Yaung, Annie Hui Nee Law, Martin Wasser, Thaschawee Arkachaisri, Andrea Hsiu Ling Low, Salvatore Albani1, J.Thumboo
  1. American College Rheumatology 2021. Lupus Low Disease Activity State Attainment Provides Significant Protection Against Mortality. A Multi-National, Longitudinal Observational Study.Kathryn Connelly, Rangi Kandane-Rathnayake, Alberta Hoi, Worawit Louthrenoo, Laniyati Hamijoyo, Jiacai Cho, Aisha Lateef, Shue Fen Luo, Yeong-Jian Wu, CS Lau, Yi-Hsing Chen, Sandra Navarra, Leonid Zamora, Zhanguo Li, Yuan An, Sargunan Sockalingam, Yanjie Hao, Zhuoli Zhang, Madelynn Chan,Yasuhiro Katsumata, Masayoshi Harigai, Shereen Oon, Sang-Cheol Bae, Sean O’Neill, Kathy Gibson, BMDB Basnayake, Jun Kikuchi, Tsutomu Takeuchi, Kristine Ng, Fiona Goldblatt, Annie Law, Nicola Tugnet, Yoshiya Tanaka, Sunil Kumar, Michael Tee, Jin Yu Tan, Chetan Karyekar, Mandana Nikpour, Vera Golder, Eric Morand
  1. American College Rheumatology 2021. APLC Association of SLE Responder Index (SRI) Attainment and Long-term Clinical Outcomes. Kathryn Connelly, Rangi Kandane-Rathnayake, Alberta Hoi, Worawit Louthrenoo, Laniyati Hamijoyo, Jiacai Cho, Aisha Lateef, Shue Fen Luo, Yeong-Jian Wu, CS Lau, Yi-Hsing Chen, Sandra Navarra, Leonid Zamora, Zhanguo Li, Yuan An, Sargunan Sockalingam, Yanjie Hao, Zhuoli Zhang, Madelynn Chan,Yasuhiro Katsumata, Masayoshi Harigai, Shereen Oon, Sang-Cheol Bae, Sean O’Neill, Kathy Gibson, BMDB Basnayake, Jun Kikuchi, Tsutomu Takeuchi, Kristine Ng, Fiona Goldblatt, Annie Law, Nicola Tugnet, Yoshiya Tanaka, Sunil Kumar, Michael Tee, Jin Yu Tan, Chetan Karyekar, Mandana Nikpour, Vera Golder, Eric Morand
  1. American College Rheumatology 2021. CXCL5 Dampens Inflammation in Murine Lupus by Orchestral Suppression of Effector Cell Proliferation and Leukocyte Extravasation. Xiubo Fan, Chin Teck Ng, Dianyang Guo, Frances Lim, Annie Law, Julian Thumboo, William Hwang and Andrea Low. 
  1. EULAR 2022. OP0142 COMPARISON OF ATTAINMENT AND PROTECTIVE EFFECTS OF THE LUPUS LOW DISEASE ACTIVITY STATE IN PATIENTS WITH NEWLY DIAGNOSED VERSUS ESTABLISHED SLE – A MULTICENTRE PROSPECTIVE STUDY. APLC group
  1. EULAR 2022. POS0121 Association of Lupus Low Disease Activity State attainment with reduced organ damage and flare in SLE patients with high disease activity. APLC collaborative Group. 
  1. EULAR 2022. POS0200 POST-MRNA VACCINE FLARES IN AUTOIMMUNE INFLAMMATORY RHEUMATIC DISEASES: INTERIM RESULTS FROM THE CORONAVIRUS NATIONAL VACCINE REGISTRY FOR IMMUNE DISEASES SINGAPORE (CONVIN-SING). Margaret M et al. 
  1. American College Rheumatology 2022 Association of Sustained Lupus Low Disease Activity State with Improved Outcomes in SLE: A Multinational Prospective Cohort Study” for presentation at ACR Convergence 2022. Vera et al. APLC collaborative Group
  1. American College Rheumatology 2022. SMART-SLE: Serology Monitoring and Repeat Testing in Systemic Lupus Erythematosus. Dr Yeo AL et al. APLC Collaborative Group. 
  1. American College Rheumatology 2022. Tapering of Corticosteroids or Immunosuppressive Therapy in Stable SLE: A Comparison of Complete Remission, Clinical Remission and Lupus Low Disease Activity State in Protection Against Flares. Cho JC et al. APLC Collaborative Group.
  1. American College Rheumatology 2022. Predictors of Organ Damage Accrual by Domains. Rangi et al. APLC Collaborative Group. 
  1. EULAR 2023: Comparison of attainment and protective effects of the Lupus Low Disease Activity State in patients with newly diagnosed versus established SLE – a multicentre prospective study. APLC Collaborative Group
  1. EULAR 2023. Association of Lupus Low Disease Activity State attainment with reduced organ damage and flare in SLE patients with high disease activity. APLC Collaborative Group
  1. EULAR 2023. Predictive correlates of arthritis and joint damage in systemic lupus erythematosus: a multinational prospective cohort study. APLC Group
  1. EULAR 2023. Risk of flare and damage accrual after tapering glucocorticoids in serologically active clinically quiescent patients with systemic lupus erythematosus. APLC Group.
  1. EULAR 2023. Informing trial measurement in systemic lupus erythematosus:  Frequency of domain-specific disease activity in a multi-national observational cohort. APLC Group
  1. EULAR 2023. A multi-dimensional approach reveals a dysregulated Systemic Lupus Erythematosus immune rheostat with an abnormal immunoregulatory response and reduced CTLA4 expression in effector T cells.
  1. EULAR 2023. Attainment of lupus low disease activity state exclusive of remission is protective against adverse outcomes in systemic lupus erythematosus. APLC Group.
  1. EULAR 2023. A multi-dimensional approach reveals a dysregulated systemic lupus erythematosus immune rheostat with an abnormal immunoregulatory response and reduced CTLA4 expression in effector T cells. JG Yeo, K Nay Yeung, Annie Law, M Wasser, T. Arkachairsri, J Thumboo, Andrea Low, Salvatore Albani. 
  1. EULAR 2023. Multiparametric Comparison of the Adult-Onset and Childhood-Onset Systemic Lupus Erythematosus (SLE) Immunomes Reveals Multiple Derangements. .  Nay Yaung K, JG Yeo, AHN Law, M. Wasser, T. Arkachaisri, KL The, YX Book, J. Thumboo, AHL Low, SL Poh, AJM Lim, Salvatore Albani. 
  1. Lupus 2023. Frequency and determinants of flare and persistently active disease in a large multinational prospective lupus cohort. APLC group
  1. Lupus 2023. Association of serologic and clinical low disease activity stares with outcomes in a large multinational lupus cohort. APLC group
  1. Lupus 2023. Towards a novel clinical outcome assessment for systemic lupus erythematosus trials – first outcomes of an international consensus process. APLC group
  1. Lupus 2023. Sub-optimal use of anti-malarial therapy for SLE in Asia Pacific Region. Observations from the Asia Pacific Lupus Cohort. APLC group
  1. Lupus 2023. Risk of flare and damage accrual after tapering glucocorticoids in serologically active clinically quiescent patients with systemic lupus erythamtosus: A multicentre observational cohort. The Asia Pacific Lupus Collaboration Cohort Study. APLC group
  1. European Paediatric Rheumatology Congress 2023. High-dimensional interrogation of the adult-onset and childhood-onset Systemic Lupus Erythematosus Immunomes.  Nay Yaung K, JG Yeo, AHN Law, M. Wasser, T. Arkachaisri, KL The, YX Book, J. Thumboo, AHL Low, SL Poh, AJM Lim, Salvatore Albani. 
  1. American College Rheumatology 2023. Neutrophils in Patients with Systemic Lupus Erythematosus Show Pronounced Inflammatory Signals. Annie Law, CJ Pua, DY Guo, CT Ng, J Thumboo, Andrea Low, Xiubo Fan.
  1. American College Rheumatology 2023. Prevalence, Determinants and Outcomes of Target Attainment in SLE Patients with Clinically Active Disease in a Large Multinational Prospective Lupus Cohort. APLC Group.
  1. American College Rheumatology 2023. End-of-Life in Systemic Lupus Erythematosus Beset by Increased Flares and Higher Treatment Burden: Data from a Prospective Large Multinational Cohort. APLC Group.
  1. American College Rheumatology 2023. Prevalence, Determinants and Outcomes of Target Attainment in SLE Patients with Clinically Active Disease in a Large Multinational Prospective Lupus Cohort. APLC Group
Achievements

Medical Teaching

Dr Annie Law enjoys teaching and has served as a caring and dedicated mentor to many medical students, junior and senior residents. She is a core faculty member of the SingHealth Rheumatology postgraduate senior residency programme, Clinical Assistant Professor at Duke-NUS Medical School, Senior Clinical Lecturer at the Yong Loo Lin School of Medicine, and a Clinical Teacher at Lee Kong Chian School of Medicine.

 

Throughout her years in SGH, Dr Law has spent countless hours educating students, residents and peers alike as evident by her numerous lectures at local programmes, seminars and conferences. She has held multiple positions ranging from clinical tutor to CME and MRCP PACES organiser. Her deep devotion to teaching is apparent during her stint in SGH. She was recognised and awarded as an outstanding faculty in the annual Residency in Singhealth Excels (RiSE) in 2019.

 

Rheumatology Society Involvement

Dr Annie Law has made significant contributions to the professional organisation for rheumatology in Singapore, advancing the knowledge and practice of rheumatology locally. She was a Committee Member and Co-opted member of the Singapore Society of Rheumatology (SSR) and held other key positions namely Organising Committee Member for SSR. She is now part of the Scientific organising committee for the upcoming Asia Pacific League of Associations for Rheumatology (APLAR) 2024.

 

This committee serves as a platform for rheumatologists to collaborate and share learnings for the betterment of its patients. Her constant involvement is a testimony of her commitment and devotion to the rheumatology society and its goals.

Associations

Academics and Research

Dr Annie Law has been actively involved in the research of SLE and was instrumental in setting up a prospective lupus database in Singapore General Hospital since 2019, which serves as a platform to better understand patients with lupus and aims to improve outcomes through advancing care and treatment of lupus patients.

 

She is actively involved in several pharmaceutical-initiated clinical trials as a principal investigator and co-investigator. She has also received multiple research grants as a fellow co-investigator with local collaborators, in studying potential biomarkers to detect flares in lupus, immune dysregulation in lupus and potential new therapy for lupus. Most notably, she is part of the research team which discovered potential protein therapy (CXCL-5) in the treatment of lupus. She aided in the collection of human samples to identify this protein which validates the findings. This finding was published in one of the top peer-reviewed rheumatology journals, Arthritis and Rheumatology in Oct 2022 and was highlighted as an important study in Nature Reviews Rheumatology.  She has also published in several peer-reviewed journals primarily on SLE with a team of esteemed researchers.

 

Furthermore, she is also part of the Asia Pacific Lupus Collaborations group, where rheumatologists with a special interest in lupus and researchers work together to improve the quality of care in lupus patients via research initiatives. Some of these works include the LLDAS validation study, treat to target SLE study and SLE outcomes study.

Awards and Honours

Dr Annie Law has devoted the last 12 years of her life to the Department of Rheumatology and Immunology at SGH, tirelessly caring for her patients. As a Senior Consultant, her role goes beyond just caring for bread-and-butter rheumatological disorders. It extends into her special interest in the lupus population, where she is intrinsically involved in and serves as the lead for the subspecialty SLE clinics. This clinic, which runs twice monthly and focuses on complex lupus patients, is one of its kind in Singapore.

Dr Law exemplifies herself as a caring and compassionate physician who always practises patient-oriented care. Her patient always comes first and in recognition of her outstanding service to her patients, she has been duly recognised by SGH with the following awards: Service with a Heart Award (2023), Heart of Gold Award (2022), Service with a Heart Award (2022), Singapore Health Quality Service Star Award (2022), Singapore Health Quality Service Silver Star Award (2018), Singapore Health Quality Service Star Award (2017), Service with a heart Award (2016), Singapore Health Service Gold Award (2016) and Singapore Health Quality Service Silver Award (2013).