Dr. Marianne Anastasia De Roza

Dr Marianne completed her Bachelor of Medicine, Bachelor of Surgery (MBBS) and Master of Medicine (MMed) in Internal Medicine at the National University of Singapore. Thereafter, she progressed to advanced specialty training in gastroenterology at Singhealth and is an accredited specialist in gastroenterology with more than 10 years of endoscopy experience. She regularly performs endoscopic procedures, including cancer screening gastroscopy and colonoscopy, as well as therapeutic interventions to remove polyps or control bleeding.

In addition, her subspecialty focus is on liver disease. She was invited to join Sengkang General Hospital as a specialist in its inaugural year and helped to set up the hepatology service which she subsequently headed from 2022-2025, expanding and leading a team comprising of specialists, specialty nurses, research and care coordinators. Having a special interest in palliative hepatology and liver cirrhosis, she further pursued a graduate diploma in palliative medicine and was director of the multidisciplinary liver supportive care programme-PEACE, a pilot programme she established for end‑stage liver disease, pioneering a new model of care which has been adopted by other hospitals. She wrote and implemented hospital protocols and served as a committee member in various workgroups for liver disease. Her research interests include fatty liver, palliation in liver disease, liver cirrhosis and its complications. She has participated in several multi-centre research collaborations with competitive grant support. Dr Marianne was actively involved in education and was appointed as Asst Professor at Duke-NUS Medical School and NUS Yong Loo Ling School of Medicine. She was also the Site Director, Core Faculty and Clinical Competency Committee member for the Singhealth Gastroenterology Senior Residency Programme. She continues to be a visiting consultant at Sengkang General Hospital.

Dr Marianne’s approach to patient care is guided by empathy and a commitment to improving quality of life for her patients. She believes in personalizing treatment plans through shared goals, with patient safety and comfort at the heart of every step.

Outside of work, she enjoys the rich flavours of Peranakan cuisine, reminiscent of her Eurasian heritage. Her happiest moments are spent with family, and she is frequently spotted at playgrounds and swimming pools or getting a caffeine fix.

Dr Marianne is a consultant in internal medicine and an accredited specialist in gastroenterology and hepatology. Her subspecialty expertise is in liver cirrhosis, portal hypertension, fatty liver disease, and palliative hepatology. She has a strong commitment to improving quality of life for patients with advanced liver disease and further pursued a graduate diploma in palliative medicine.

1) Hyperammonemia predicts the development of liver-related events in a prospective cohort of stable cirrhosis patients, Hepatology Communications 2025 (accepted publication in press)
2) Nagarajan Venkatchocku Ashok Annamalai, Garrett Kang, Marianne Anastasia De Roza; A Case Report on Plasma Exchange for Acute-on-Chronic Liver Failure from Severe Alcoholic Hepatitis with Failed Steroid Therapy. Case Rep Gastroenterol 1 January 2025; 19 (1): 597–604. https://doi.org/10.1159/000547521
3) Chang, J.P.-E., Lin, H.-Y., Loi, P.-L., Ng, J.P.-X., De Roza, M., Kumar, R., Tan, H.-K., Ho, C.K., Teo, W.-Q., Chung, A.H.H. and Raj, P. (2025), Validation of ICD-10 Consensus Code Set for Cirrhosis Detection Using Electronic Health Records in an Asian Population. JGH Open, 9: e70156. https://doi.org/10.1002/jgh3.70156
4) Yu Jun Wong, Adam Buckholz, Alyssa Sim, Margaret Teng, Rochelle Wong, Michael P. Curry, Marianne Anastasia De Roza, Gyorgy Baffy, Xuhui Teoh, Eric Chak, Tarun Rustagi, Jason Chang, Guan Wee Wong, Puneeta Tandon, Guadalupe Garcia-Tsao, Juan G. Abraldes, Arpan Mohanty, Brett Fortune, Nonalcohol-related Cirrhosis Leads to Higher 6-week Mortality After Acute Variceal Bleeding Than Alcohol-related Cirrhosis, Clinical Gastroenterology and Hepatology https://doi.org/10.1016/j.cgh.2024.10.022.
5) Yu Jun Wong, Margaret Teng, Alyssa Sim, Htay Myat Thet, Xuhui Teoh, Marianne Anastasia De Roza, Guan Sen Kew, Pooi Ling Loi, Kai Lim, Garrett Kang, Jonathan Kuang, En Xian Sarah Low, Jing Liang Ho, Liu Yuan Gabriel Cher, Kenny Sze, Guan Wee Wong, Boon Yew Andrew Kwek, Wei Lyn Yang, Juan G Abraldes, Jason Chang; Full adherence to cirrhosis quality indicators is associated with lower mortality in acute variceal bleeding: Nationwide audit.” Hepatology (2024): 10-1097.
6) De Roza MA, Lamba M, Goh GBB, Lum JHM, Cheah MCC, Ngu JHJ. Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome: A prospective multi-centre cohort study. World J Gastroenterol 2021; 27(43): 7563-7571
7) De Roza MA, Kai L, Kam JW, Chan YH, Kwek A, Ang TL, Hsiang JC. Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis. World J Gastroenterol 2019; 25(33): 4933-4944
8) De Roza MA, Goh GB; The Increasing Clinical Burden of NAFLD in Asia. Lancet Gastroenterol Hepatol 2019 May;4(5):333-334
9) De Roza MA, Lim CH; Eosinophilic cholangitis treatment with budesonide, World J Hepatol. 2017 Dec 28;9(36):1385-1388.
10) De Roza MA, Quah KH, Tay CK, Toh W, Li H, Kalyanasundaram G, Anantham D; Diagnosis of Peripheral Lung Lesions via Conventional Flexible Bronchoscopy with Multiplanar CT Planning; Pulm Med. 2016;2016:5048961.
(i) Abstracts
1) Marianne Anastasia De Roza, Danielle Ho, Su Qiqi, Charlene Tan Huimin, Aiden Lin Yuda, Koh Guan Hong, Jolyn Tan, Lionel See; Development of the Palliate End-stage and Advanced Cirrhotics Early (PEACE) Liver Supportive Care Programme: Lessons and early outcomes from a multidisciplinary approach to providing palliation for liver cirrhosis patients in Singapore. The Liver Meeting, American Association for the Study of Liver Diseases (AASLD), 2025
2) Cheryl Huang, Marianne Anastasia De Roza; Using the Integrated Palliative Care Outcome Scale (IPOS) for Symptom Assessment: A Prospective Study in a Liver Supportive Care Program in Singapore. The Liver Meeting, American Association for the Study of Liver Diseases (AASLD), 2025
3) Yi-Chun WANG, Jeremy Wei Song CHOO, Sulaiha Binte ITHNIN, Guan Huei LEE, Marianne Anastasia DE ROZA, Kok Kiong ONG, Patricia Ching Yen CHIA, Kee Tung TAN, Ngiap Chuan TAN, Han Chong TOH, Oi Fong CHONG, Jason Pik Eu CHANG, Wei Lyn YANG, Xin Yi YEAP, Kate HALKERSTON, Daniel BULTE, Michael BRADY, Pierce CHOW; Quantifying increased confidence in ruling out HCC using liver function tests and quantitative MRI, Asian Pacific Association for the Study of the Liver (APASL), 2025
4) Danelle Lai, Marianne Anastasia De Roza; Advanced Care Planning for Liver Cirrhosis Patients in Singapore: Barriers to ACP and Influence of HCC Diagnosis on ACP Preferences, Asian Pacific Association for the Study of the Liver (APASL), 2025
5) Charlene Yeo, Marianne Anastasia De Roza, Gaps in palliative care for liver cirrhosis: An analysis on disease burden, timing and utilization of palliative services, Asian Pacific Association for the Study of the Liver (APASL), 2025
6) Nagarajan Venkatchocku Ashok Annamalai, Marianne Anastasia De Roza; Plasma Exchange for Acute-on-Chronic Liver Failure from Severe Alcoholic Hepatitis with Failed Steroid Therapy, Asian Pacific Digestive Week (APDW) 2024
7) Jason Pik Eu CHANG, Jin YU, Oi Fong CHONG, Jeremy Wei Song CHOO, Sulaiha Binte ITHNIN, Guan Huei LEE, Marianne Anastasia DE ROZA, Kok Kiong ONG, Patricia Ching Yen CHIA, Kee Tung TAN, Ngiap Chuan TAN, Han Chong TOH, Yu Jun WONG, Wei Lyn YANG, Xin Yi YEAP, Cheryl Min En CHUA, Cheng HE. Pierce CHOW, Diagnostic accuracy of microRNAs as non-invasive biomarkers for the diagnosis of liver cirrhosis, Asian Pacific Association for the Study of the Liver (APASL), 2024
8) Rajamanickam Chandrasekaran Kalki , Adrienne Chew Yu Hsiang , Bryan Loh Guan Jie ,Garrett Kang Junhui , Clarence Kwan Kah Wai , Marianne Anastasia De Roza; Endotracheal Intubation and Longer Inpatient Stay are Associated with Recurrence of Variceal Bleeding, Asian Pacific Association for the Study of the Liver (APASL), 2024
9) Martin Putera, Farah Gillian Irani, Lin Cui Li, Marianne Anastasia De Roza; Treatment of Bleeding Rectal Varices with Portosystemic Collaterals Refractory to Endoscopic Therapy; Asian Pacific Association for the Study of the Liver (APASL), 2024
10) Aaron Thio Heng Kai, Marianne Anastasia De Roza; Autoimmune Hepatitis Triggered by Covid-19 Vaccination: Safety of Repeat Dosing; Asian Pacific Association for the Study of the Liver (APASL), 2024
11) Benjamin NAH, Guan Huei LEE, Lydia LIM, Kaiyee TOH, Oi Fong CHONG, Jeremy WeiSong CHOO, Sulaiha Binte ITHNIN, Jason PikEu CHANG, Marianne Anastasia DE ROZA, Kok Kiong ONG, Patricia Ching Yen CHIA,Kee Tung TAN,Ngiap Chuan TAN,Han Chong TOH,Yu Jun WONG,Wei Lyn YANG, Xin Yi YEAP,Brian Kim Poh GOH, Glenn BONNEY, Adrian CHIOW,Vishal G SHELAT,Juinn Huar KAM,Cheryl Min En CHUA,Wei Jie LEE, Jeremy LIM,Pierce CHOW, A MICROBIAL SIGNATURE RISK SCORE FOR PREDICTION OF HEPATOCELLULAR CARCINOMA (HCC), Asian Pacific Digestive Week 2023
12) Teng Kiat KOH, Guan Huei LEE, Lydia LIM, Kaiyee TOH, Oi Fong CHONG, Jeremy Wei Song CHOO, Sulaiha Binte ITHNIN, Jason Pik Eu CHANG, Marianne Anastasia DE ROZA, Kok Kiong ONG , Patricia Ching Yen CHIA , Kee Tung TAN , Ngiap Chuan TAN , Han Chong TOH , Yu Jun WONG , Wei Lyn YANG, Xin Yi YEAP, Brian Kim Poh GOH, Glenn BONNEY, Adrian CHIOW, Vishal G SHELAT, Juinn Huar KAM,Cheryl Min En CHUA , Jacelyn Siou Sze CHUA, Jade Shu Qi GOH, Kyra Joyce YEO, Yu Ki SIM, Jonathan Wei Jie LEE , Jeremy LIM, Pierce CHOW; MICROBIAL FEATURES IN PATIENTS WITH HEPATOCELLULAR CARCINOMA: A PILOT CROSS-SECTIONAL STUDY; Asian Pacific Digestive Week 2023
13) Yu Jun Wong, Margaret Li Peng Teng, Alyssa Sim, Marianne Anastasia De Roza, Jia Hong Koh, Guan Sen Kew, Garrett Kang, Jonathan Kuang, Htay Myat Thet, En Xian Sarah Low, Kai Lim, Pooi Ling Loi, Xuhui Teoh, Gabriel Liu Yuan Cher, Jing Liang Ho, Siti Maryam Abdul Rahman, Kenny Sze, Guan Wee Wong, Andrew Kwek, Wei Lyn Yang, Jason Pik Eu Chang; Portal Vein Thrombosis Predicts Higher Mortality in Cirrhosis Patients with Acute Variceal bleeding: A Singapore Nationwide AVB Audit. Hepatology. (The Liver Meeting 2023)
14) Marianne Anastasia De Roza, Teo Wei Quan, Amber Chung, Chang Pik Eu Jason, Rahul Kumar, RC Kalki , Kevin Teh, Tan Hiang Keat, Prema Raj,Chanda Ho; The hospital frailty risk score identifies liver cirrhosis patients at risk of frailty and mortality. Hepatology Oct 2023 Vol 78 Issue S3816
15) Yu Jun Wong, Margaret Teng, Alyssa Sim, Marianne Anastasia De Roza, Garrett Kang, Kew Guan Sen, Jonathan Kuang, Kenny Sze, Wong Guan Wee, Yang Wei Lyn, Jason Chang. Real World Practice of Pre-emptive TIPPS: Asia Perspective Based on Singapore Nationwide Variceal Bleeding Audit. Journal of Hepatology Volume 78, S300
16) Yu Jun Wong, Alyssa Sim, Li Peng M. Teng, Marianne Anastasia De Roza, Garrett Kang, Jonathan Kuang, Jason Chang. High Compliance of AASLD Cirrhosis Quality Measures is Associated with Improved Outcomes in Cirrhosis with Acute Variceal Bleeding: Singapore Nationwide Audit. Gastroenterology, Vol 164 Issue 6, S1268
17) Elisabeth Sarah Pickles, John Connell, Stella Nay Kyi Kin, Alison Telford, Arina Kazimianec, Michael Brady, Daniel Bulte, Oi Fong Chong, Han Jun Choo, Sulaiha Binte Ithnin, Jason Pik Eu Chang, Guan HueiLee, Marianne Anastasia De Roza, Kok Kiong Ong, Sabrina Yi-Mei Wee, Kee Tung Tan, Ngiap Chuan Tan, Han Chong Toh, Yu Jun Wong, Wei Lyn Yang, Xin Yi Yeap, Cheryl Min En Chua, Jacelyn SiouSze Chua, Jade Shu Qi Goh, Lynette Soh Han Lai, Yu Ki Sim, and Pierce K.H. Chow, SENSE and Compressed SENSE chemical shift encoded multi-gradient echo for T2*quantification in the liver. ISMRN 2022 https://archive.ismrm.org/2022/1937.html
18) De Roza, Marianne A, Tiing Leong Ang, Andrew Kwek, Kwong Ming Fock, Eng Kiong Teo, John C Hsiang; Long Term Use of Proton Pump Inhibitors Increases Mortality and Hepatic Decompensation in Patients with Decompensated Liver Cirrhosis. Gastroenterology, Volume 156, Issue 6, S-1189 – S-1190
19) Mehul Lamba, Marianne A. De Roza, Catherine A Stedman, Huey Ming Johnathan Lum, George Goh, Jing Hieng Ngu; Autoimmune Markers in NASH predict Clinical Outcome: Multicentre Observational Study. Gastroenterology, Vol 156, Issue 6, S-1216
20) M. A. De Roza, A. Ong, Y.K Ng, P. Ghosh, Y. T. Wang; Joint hypermobility syndrome in patients with functional gastrointestinal disorders: A prevalence study in Singapore Neurogastroenterology and Motility Aug 2018 Volume 30, Issue S1, Page104 P257
21) Y.K. Ng, M. A. De Roza, A.M.L. Ong, Y. Hao, K. Doshi, Y.T. Wang; Pilot feasibility analysis of mindfulness based cognitive therapy (MBCT) for functional dyspepsia in a Tertiary Referral Centre in Singapore Neurogastroenterology and Motility Aug 2018 Volume 30, Issue S1 Page107 P262
22) M De Roza, JH Chen; The Indication, dosage and duration of proton pump inhibitors in liver cirrhosis; Journal of Hepatology. April 2018 Volume 68, S747 doi: https://doi.org/10.1016/S0168-8278(18)31756
23) Marianne Anastasia De Roza, Lim Kai, John Chen Hsiang; Proton pump inhibitor use in liver cirrhosis. Hepatol Int. 2018 Mar 7, S558
24) MA De Roza, TT Tey, YT Wang, Vikneswaran; The usage of Proton Pump Inhibitors in Singapore; J Gastroenterol Hepatol Sept 2017 Volume 32, S3P70