Dr. Michelle Kam Michelle Kam

Dr Michelle Kam is a Senior Consultant pulmonologist at O2 Lung Centre and a visiting consultant at Singapore General Hospital (SGH). She currently serves as the Asian Pacific Society of Respirology (APSR) Interstitial Lung Disease (ILD) Assembly Deputy Head.

Dr Kam specializes in respiratory medicine and treats conditions including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and chronic cough. She also performs procedures including bronchoscopy and endobronchial ultrasound (EBUS). Her clinical interests are in ILD and rare lung diseases. She completed a subspecialty fellowship in ILD and orphan lung diseases, at National Jewish Health, a leading respiratory center in the USA, with one of the largest and most established ILD programs in the nation. During her fellowship, she also received training in sarcoidosis and granulomatous lung disease, orphan and cystic lung disease (e.g. lymphangioleiomyomatosis (LAM), Birt-Hogg Dube Syndrome, pulmonary Langerhans cell histiocytosis), childhood ILD and pulmonary genetics.

Prior to private practice, Dr Kam was associate director of the HHT treatment centre at SGH and established a cystic lung disease clinic. She was part of a multidisciplinary workgroup for immunotherapy-related toxicities at National Cancer Centre Singapore (NCCS) and was involved in combined Respiratory and Rheumatology clinics at SGH.

Dr Kam has received various awards, including the Class of 1975 Book Prize, Singhealth Best House Officer Award and Service with a Heart Award. More recently, she received the inaugural Singapore Thoracic Society Young Investigator’s Award in 2022, as well as the 2025 ATS-APSR Travel Award. She is well-published in international peer-reviewed journals and has been an invited speaker and faculty member at local, regional and international conferences.

Selected Publications

1. Validation of the ILD-GAP Model and a local nomogram in a Singaporean Cohort

MLW Kam, HH Li, YH Tan, SY Low.

Respiration 2019;98(5):383-390.

2. Telomere Biology Disorders

MLW Kam, TTT Nguyen, JYY Ngeow

npj Genomic Medicine npj Genomic Medicine (2021) 6(1):36

3. Country-wide genotyping of Mycobacterium tuberculosis complex in Singapore, 2011-2017

MLW Kam, LKY Lim, LH Sng, RTH Ong, VJM Lee, YT Wang, CBE Chee,

Tuberculosis 2022 (134), 102204

4. The road to hell is paved with good intentions: a look back at the PANTHER-IPF trial

M Kam, J Caliez, H Nunes, T Gille

Breathe 2022 18: 220074

5. Cluster phenotypes in a non-idiopathic pulmonary fibrosis fibrotic interstitial lung diseases cohort in Singapore

MLW Kam, PY Tiew, HZ Chai, SY Low

Journal of Thoracic Disease 2022;14(7):2481-2492

6. First ever characterisation of the effects of short telomeres in a Singapore interstitial lung disease cohort

Kam MLW, Chong ST, Chan SH, Swigris JJ, Chew EL, Tan YH, Ngeow JYY, Low SY.

Respir Investig. 2024;62(3):348-355

7. Quantitative CT Scan Analysis in Rheumatoid Arthritis-Related Interstitial Lung Disease

SM Humphries, A Adegunsoye, MK Demoruelle, MLW Kam, I Amigues, TJ Bang, SD Teague, DA Lynch, JH Chung, ME Strek, JJ Swigris, JJ Solomon.

Chest. 2024 Nov 9:S0012-3692(24)05472-2. doi: 10.1016/j.chest.2024.10.052. PMID: 39528110.

8. Development and Validation of a Clinical, CT, Genomic Classifier and BAL Scoring System for Diagnosing IPF.

Kam MLW, Tjong EL, Chaudhary S, Koelsch TL, Pryor JB, Koslow M, Mohning MP, Solomon JJ, Huie TJ, Swigris JJ, Fernández Pérez ER.

Eur Respir J. 2025 Jan 16:2401077. doi: 10.1183/13993003.01077-2024. PMID: 39819571

Selected Abstracts

1. 4–year trajectory of medication adherence amongst severe asthma patients: Risk factors and impact on asthma control

LL Tan, MLW Kam, ACA Yii, Q Cao, MC Kong, MHH Cheen, S Nallappen, KY Ong, TS Lapperre, MS Koh

ERS International Congress 2016 (London, United Kingdom)

2. Case series of occupational asthma in healthcare workers diagnosed at a tertiary referral clinic

M.L. Kam; M. Seng; K. Choy; K.L. Tan

CHEST 2017 (Toronto, Canada)

3. Reverse halo sign in a middle-aged female with neutropenic sepsis following chemotherapy for acute lymphoblastic leukaemia

M.L. Kam; L.T. Cheng, N.H. Chan, D. Tan, H.J. Ng, K.L. Tan

CHEST 2017 (Toronto, Canada)

4. The Use of Extracorporeal Membrane Oxygenation in Severe Adenovirus Pneumonia Complicated by Acute Respiratory Distress Syndrome: A Single Centre Experience

M. L. Kam, H. Chai, K. Goh, Q. Tan, D. Sewa, A. Tan, M. Tay, G. Phua

CHEST 2017 (Toronto, Canada)

5. Validation of the ILD-GAP model in a Singapore population

M.L. Kam, HH Li, YH Tan, SY Low

ERS International Congress 2018 (Paris, France)

6. Noninvasive Ventilation for Patients With COPD Exacerbation and a Do-Not-Intubate Order

IG Lee, MLW Kam, CWS Teo, MS Koh, CK Tay

AARC Congress 2018 (Las Vegas, USA)

7. Baseline CT thorax fibrosis using a cutoff of 10% alone does not portend a poorer prognosis in non-IPF ILD

M. Kam, YH Tan, SY Low

ERS International Congress 2020 (Virtual Congress)

8. Short leukocyte telomere lengths correlate with poorer survival and absolute FVC decline from baseline independent of ILD diagnosis

MLW Kam, ST Chong, EL Chew, SH Chan, NDB Ishak, SY Low, JYY Ngeow

APSR Congress 2022 (Seoul, South Korea)

9. Cancer in patients with interstitial lung disease (ILD) in a tertiary hospital in Singapore: A retrospective cohort study

WP Koh, YH Tan, CSIG Phua, MBM Nor, MLW Kam, SY Low

APSR Congress 2023 (Singapore)

10. Adding an Exposure History and BAL Fluid Analysis to an Envisia Genomic Classifier Test Enhances IPF Diagnostic Confidence

MLW Kam, ER Fernandez Perez

American Thoracic Society International Conference 2024 (San Diego, California, United States of America)

11. Bookmarking Dyspnea in Fibrotic Interstitial Lung Disease

J Swigris, K Aronson, M Kam

Thomas L. Petty Aspen Lung Conference 66th Annual Meeting “Pulmonary Fibrosis – Focusing on the Future” 2024 (Aspen, Colorado, United States of America)

12. Referral and uptake patterns for genetic counselling and testing in interstitial lung disease patients: A tertiary referral centre experience in South-East Asia

MLW Kam, EL Chew, ST Chong, SH Chan, NDB Ishak, SY Low, JYY Ngeow

APSR Congress 2024 (Hongkong SAR)

13. Baseline characteristics of a prospective multi-centre study characterizing epidemiology and disease behaviour of interstitial lung diseases in Singapore (ILD-Sing)

GT Chai, Z Ng, YH Tan, MLW Kam, V Lim, AY Li, FSW Teo, SY Low

APSR Congress 2024 (Hongkong SAR)

14. A Baseline HRCT Deep Textural Analysis Fibrosis Score of>= 10% in RA-ILD Is Associated With an Increased Risk of All-cause Mortality

MLW Kam, J Pryor, K Demoruelle, S Matson, JJ Swigris, SM Humphries, J Solomon

American Thoracic Society International Conference 2025 (San Francisco, California, United States of America)

15. Predictive Value of Fibrosis Scoring and Genomic Classifier in Patients With ILD

J Pryor, JJ Swigris, MLW Kam, M Koslow, SM Humphries, J Solomon.

American Thoracic Society International Conference 2025 (San Francisco, California, United States of America)

16. Genomic Testing of Patients with Interstitial Lung Disease: Current International Practice

SC Stanel, TJ Corte, G Lough, AO Adegunsoye, FM Aguiar, F Bonella, R Borie, I Buendia-Roldan, A Duckworth, A Froidure, GM Hunninghake, KJ Hurley, KAM Johannson, MLW Kam, T Kulkarni, J Mackintosh, M Molina-Molina, C Newton, EA Renzoni, D Zhang, P Rivera Ortega

American Thoracic Society International Conference 2025 (San Francisco, California, United States of America)

17. Characteristics of Progressive Pulmonary Fibrosis According to 2022 ATS/ERS Guidelines in a Singapore ILD Cohort

MLW Kam, IGCS Phua, MBM Nor, WP Tham, SMH Mohideen, AM Takano Pena, XM Cheng, YH Tan, BLW Chua, SY Low

APSR Congress 2025 (Manila, Philippines)

Leadership
Associate Director, Singapore General Hospital Hereditary Hemorrhagic Telangiectasia (HHT) Treatment Centre (2023-2026)
Deputy Head, Asian Pacific Society of Respirology (APSR) Interstitial Lung Disease (ILD) Assembly (2025-present)

Research Grants
Boehringer Ingelheim Investigator-Initiated Grant: Genetics in Interstitial Lung Disease (2020)
Singapore General Hospital Research Grant (2022)
Singhealth Nurturing Clinician Scientist Award (2022)
Precision Health Research Singapore (PRECISE) Grant (2024)

Education
Physician Faculty/Internal Medicine/Singhealth Residency Program (2019-2026)
Physician Faculty/Respiratory Medicine/Singhealth Senior Residency Program (2019-2026)
Clinical Assistant Professor/ Duke-NUS Medical School (2023-present)
Clinical Teacher/Lee Kong Chian School of Medicine (2023-present)
Clinical Lecturer/Yong Loo Lin School of Medicine (2024-present)

Asian Pacific Society of Respirology: Fellow

American Thoracic Society: Member

European Respiratory Society: Member