Dr. Prem Thurairajah
Gastroenterology (Stomach & Digestive System)
| Credentials | MBBS, MRCP (UK), PhD, FRCP (UK) |
|---|---|
| Language | English, Bahasa Melayu, Tamil, Bahasa Indonesia |
| Info | Dr. Prem Thurairajah is a Senior Consultant Gastroenterologist and Hepatologist with over 25 years of international clinical and academic experience across the United Kingdom, United States, and Singapore. He trained in Internal Medicine and Gastroenterology through the West Midlands Deanery in Birmingham, UK, and completed specialized subspecialty fellowships in Transplant Hepatology and Hepatobiliary Endoscopy. He holds a double fellowship from the Queen Elizabeth Hospital Liver Unit, Birmingham, and University College London (UCL), specialising in complex liver disease and therapeutic complex endoscopic procedures in cancer detection, ERCP and EUS. Dr. Prem has served as a Consultant Transplant Hepatologist at St James’s University Hospital, Leeds, and later as an Assistant Professor at the University of Kentucky, USA, where he managed patients with advanced liver disease and contributed to academic teaching and research. In addition to clinical practice, Dr. Prem completed a PhD in Immunology and Chronic Viral Hepatitis at the University of Plymouth, supported by a UK National Health Service research grant. His work in community-based Hepatitis C care has influenced public health practice and earned the Best Publication Award from the Singapore Medical Association. He has published over 30 peer-reviewed scientific papers in hepatology and gastroenterology. In Singapore, he previously served as Director of Hepatology at Changi General Hospital and as a Senior Consultant at the National University Hospital (NUH). He was core faculty within both the SingHealth and NUHS residency programmes, training senior residents and fellows in gastroenterology and hepatology. His clinical practice today focuses on evidence-based, patient-centred care, combining targeted diagnostics, modern endoscopy, and thoughtful long-term management of digestive and liver diseases. |
| Associated Treatments | Oesophago-gastro-duodenoscopy (OGD) Colonoscopy Endoscopic Retrograde Cholangio-Pancreatography (ERCP) Endoscopic Ultrasound (EUS) Complex Liver Disease and Liver Transplant Assessment |
| Publications | Late acute liver allograft rejection; a study of its natural history and graft survival in the current era Thurairajah PH, Carbone M, Bridgestock H, Thomas P, Hebbar S, Gunson BK, Shah T, Neuberger J • Transplantation • 2013 Loss of virus-specific T cell responses in HCV exposed uninfected injection drug users with drug rehabilitation Thurairajah PH, Hegazy D, Demaine A, et al. • J Infect Dis • 2011 Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus Thurairajah PH, Khanna A, Mutimer D • J Viral Hepatitis • 2010 HCV-specific T cell responses in injection drug users with apparent resistance to HCV infection Thurairajah PH, Hegazy D, Chokshi S, et al. • J Infect Dis • 2008 Incidence and characterization of elevations in serum transaminases in pegylated interferon and ribavirin treated patients Thurairajah PH, Thorburn D, Hubscher S, et al. • Aliment Pharmacol Ther • 2007 Orlistat (Xenical) induced liver failure Thurairajah PH, Syn W, O’Neil D, Stell D, Haydon G • Eur J Gastroenterol Hepatol • 2005 Endoscopic closure of a non healing gastrocutaneous fistula following PEG removal Thurairajah PH, Hawthorne AB • Endoscopy • 2004 A Painful Swollen Calf Thurairajah PH, Browne S, Bondeson J • J R Soc Med • 2003 What is required for achieving hepatitis C virus elimination in Singapore? A modeling study Chaillon A, Thurairajah PH, Hsiang JC, Martin NK • J Gastroenterol Hepatol• 2021 Efficacy and safety of sofosbuvir/velpatasvir in a real-world chronic hepatitis C genotype 3 cohort Wong YJ, Thurairajah PH, Kumar R, Tan J, Fock KM, Law NM, et al. • J Gastroenterol Hepatol • 2021 The impact of unrestricted access to direct-acting antiviral among incarcerated hepatitis C virus-infected patients Wong YJ, Thurairajah PH, Kumar R, Fock KM, Law NM, Chong SY, et al. • Clin Mol Hepatol • 2021 Novel non-invasive score to predict cirrhosis in the era of hepatitis C elimination: A population study of ex-substance users in Singapore Zhao Y, Thurairajah PH, Kumar R, Tan J, Teo EK, Hsiang JC • Hepatobiliary Pancreat Dis Int • 2019 Interleukin 12B gene polymorphism and apparent resistance to hepatitis C virus infection Hegazy D, Thurairajah PH, Metzner M, et al. • Clin Exp Immunol • 2008 Autochthonous hepatitis E in southwest England Dalton HR, Thurairajah PH, Fellows HJ, et al. • J Viral Hepatitis • 2007 Clinical implications of prompt ascitic drain removal among cirrhosis with refractory ascites Wong YJ, Lum HM, Tan PT, Teo EK, Tan J, Kumar R, Thurairajah PH • Singapore Med J • 2021 Point-of-care hepatitis C screening with direct access referral to improve linkage of care among people with substance misuse: a pilot randomised study Hsiang JC, Sinnaswami P, Lee MY, Zhang MM, Quek KE, Tan KH, Wong YM, Thurairajah PH • Singapore Medical Journal • 2020 Economic evaluation of direct-acting antivirals for the treatment of genotype 3 hepatitis C infection in Singapore Wong YJ, Cheen MH, Hsiang JC, Kumar R, Tan J, Teo EK, Thurairajah PH • JGH Open • 2019 Ombitasvir/paritaprevir/ritonavir+daclatasvir and ribavirin associated drug induced liver injury and syndrome of inappropriate secretion of antidiuretic syndrome: A case report Kumar R, Hsiang JC, Tan J, Thurairajah PH • Clin Mol Hepatol • 2019 Comparative study of strategies for preventing post-ERCP pancreatitis after early precut sphincterotomy for biliary access Ang TL, Kwek AB, Song M, Li JW, Thurairajah PH • J Dig Dis • 2016 Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: A meta-analysis Loo JH, Xu WXF, Low JT, Tay WX, Ang LS, Tam YS, Thurairajah PH, Kumar R, Wong YJ • World Journal of Hepatology • 2022 Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-arterial Chemoembolization and Radiofrequency Ablation Tay BWR, Huang DQ, Muthiah M, et al. • Biomedicines • 2022 Hepatitis C elimination among people incarcerated in prisons: challenges and recommendations for action within a health system framework Akiyama MJ, Kronfli N, Cabezas J, Sheehan Y, Thurairajah PH, Lines R, Lloyd AR; INHSU–Prisons Network • Lancet Gastroenterol Hepatol • 2021 Novel albumin, bilirubin and platelet criteria for the exclusion of high-risk varices in compensated advanced chronic liver disease: A validation study Wong YJ, Kew GS, Tan PS, Chen Z, Putera M, Yip WA, Thurairajah PH, et al.• Clin Res Hepatol Gastroenterol • 2021 The difference in histology yield between 19G EUS-FNA and EUS-fine-needle biopsy needles Ang TL, Li JW, Kwek ABE, Thurairajah PH, Wang LM • Endosc Ultrasound • 2019 Alcohol-Related Liver Disease Is Rarely Detected at Early Stages Compared with Liver Disease of Other Etiologies Worldwide Shah ND, Ventura-Cots M, Abraldes JG, et al. • Clin Gastroenterol Hepatol• 2019 VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature Wong YJ, Chew SY, Hsiang JC, Thurairajah PH, Kumar R, Teo EK, Gokhale RS, Noor IBM, Tan J • Clin Mol Hepatol • 2019 TC-325 versus the conventional combinational combined technique for endoscopic treatment of peptic ulcers with high-risk bleeding stigmata: A randomized pilot study Kwek BEA, Ang TL, Ong PLJ, Tan YLJ, Ang SWD, Law NM, Thurairajah PH, Fock KM • J Dig Dis • 2017 Is narrow band imaging superior to high-definition white light endoscopy in the assessment of diminutive colorectal polyps? Singh R, Bhat YM, Thurairajah PH, Shetti MP, Jayanna M, Nind G, Tam W, Walmsey R, Bourke M, Moss A, Chen R, Bampton P, Roberts-Thomson I, Schoeman M, Tucker G • J Gastroenterol Hepatol • 2013 Cytokine profiles in high risk injection drug users suggests innate as opposed to adaptive immunity in apparent resistance to hepatitis C virus infection Warshow UM, Riva A, Hegazy D, Thurairajah PH, Kaminski ER, Chokshi S, Cramp ME • J Viral Hepatitis • 2012 Role of narrow band imaging in Barrett’s Oesophagus Singh R, Nordeen N, Shanmuganathan G, Thurairajah PH, Bhat YM • Digestive Endoscopy • 2011 Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease Dalton HR, Stableforth W, Thurairajah PH, et al. • Eur J Gastroenterol Hepatol • 2008 Autochthonous hepatitis E in Southwest England: a comparison with hepatitis A Dalton HR, Stableforth W, Hazeldine S, Thurairajah PH, et al. • Eur J Clin Microbiol Infect Dis • 2008 Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM Response Bendall R, Ellis V, Ijaz S, Thurairajah PH, Dalton HR • J Med Virol • 2008 The role of hepatitis E virus testing in drug-induced liver injury Dalton HR, Fellows HJ, Stableforth W, Joseph M, Thurairajah PH, et al. • Aliment Pharmacol Ther • 2007 |
| Associations | Singapore Medical Association (SMA) |
| Awards and Honours | BSG/Keymed sponsored Advance Endoscopy Symposium Medical University of South Carolina. EASL School of Hepatology sponsored symposium Philip Haige Award – Best Oral Presentation in Viral Hepatitis, British Association of the Study of Liver Diseases South West Gastro Society Fellowship |
| Fellowships and Accreditations | Transplant Hepatology – Queen Elizabeth Hospital, Birmingham, UK Advanced Hepatobiliary Endoscopy (ERCP & EUS) – University College London, UK |
